AICAR, also known as AICA ribonucleotide, is transitional within the generation of inosine monophosphate. Its scientific name is 5-Aminoimidazole-4-carboxamide ribonucleotide and can sometimes be referred to as ZMP or Acadesine. Its function is to stimulate AMP-protein kinase processes in the body, which then promote use of stored nutrient for energy production. As a matter of fact, AICAR is best used as part of an endurance stack and has been utilized by athletes to enhance their performance. Essentially, it increases the amount of blood flow throughout the body, which in turn elevates levels of glucose intake and oxygen receipt on a cellular level by blocking enzymes both in extracellular and intracellular levels. These processes allow for more energy conversion thereby helping sustenance of a more evenly controlled metabolic state.

How Does AICAR Work?


5-Aminoimidazole-4-carboxamide ribonucleotide, commonly abbreviated as AICAR, helps trigger AMP-activated protein kinase thereby leading to increased glucose uptake by the cells of skeletal muscles.

In a series of experiments conducted by The Howard Hughes Medical Center and Salk Institute in the 2000s, it was found out that AICAR helped boost energy levels and endurance in mice by up to 44 percent. According to this research, it was concluded that the mice administered with this peptide showed significant improvements in endurance when subjected to intense exercises. While the basis of this research was not specified, it was conjectured that this improvement helped to prove AICAR’s ability to promote conversion of fast-jerk muscle fibers to slow jerk muscle fibers. This conversion stimulates a higher rate of energy efficiency in cells while also promoting quicker fat burning amongst the test subjects.

Following this study, the popularity of AICAR among endurance athletes looking to boost their performance rose tremendously.

AICAR works by increasing the activities of p38 nitrogen-activated protein kinases A and B in the cell of skeletal muscle tissues. It also stimulates glucose uptake by skeletal muscle tissues. Additionally, its ability to reduce reactive oxygen compounds inside body cells helps to suppress apoptosis. In a nutshell, AICAR increases the fuel responsible for regulation and maintenance of skeletal muscle tissue thereby prolonging the life of their cells.

AICAR also works by tricking your body to think that an exercise has been performed. This makes the energy cycle at the cellular level to start converting fuel sources such as fatty acids (that would have been used during exercises) to energy. This can significantly impact your level of endurance when conducting workouts.

Finally, insulin sensitivity is another of the actions triggered by AICAR as your body is made to think it went through a series of exercises. Ultimately, this helps to boost your energy levels.

How to use AICAR


To use AICAR, you must be a top-level endurance athlete or bodybuilder as the dosage recommended to achieve its full benefits is extremely high. AICAR is dosed at about 500mcgs per kilogram of body weight. This dosage coupled with its steep prices means that AICAR tends to be out of reach for a majority of bodybuilders and endurance athletes. Just to give you an idea, a gram of pure AICAR can cost in excess of $100 which means that a single dosage could cost several hundreds of dollars. And even if you had to circumvent by stacking it with other supplements, you would still need to spend considerable amounts of money and perhaps fail to see desired results if not using the recommended dosage.

Peptide AICAR has amazing properties and benefits including slowing down growth of cancer cells. Unfortunately, for the average bodybuilder or athletes, it cannot be administered on a day to day basis mainly due to its cost. But for advanced endurance athletes and professional bodybuilders, this peptide will guarantee amazing results especially if the recommended dosage is observed.

Benefits of AICAR


Enhances Uptake of Glucose

According to scientific research based on animal test subjects, this peptide has shown to increase uptake of glucose along with two other dietary monosaccharides- galactose and fructose. Normally, these three are absorbed directly into the bloodstream during digestion, where they are utilized as secondary sources of energy and metabolic intermediaries.

These studies revealed that AICAR increases synthesis of glycogen – the multi-branched polysaccharide that serves as an energy storage in animals. The increased uptake and synthesis of glycogen leads to an elevated rate of protein production. This speeds up the process of building and repairing worn out skeletal muscle tissue. The same applies to the human body.

Helps Combat Insulin Resistance

AICAR has shown unique ability to combat insulin resistance in various scientific researches. Insulin resistance is a physiological condition whereby cells are unable to respond to normal reaction caused by insulin secretion. Fortunately, administration of AICAR can help lower this condition while also increasing glucose uptake. In the end, it promotes growth and repair of skeletal and muscular tissues.

Aids in Energy Regulation and Escalation

AICAR’s ability to increase glucose uptake and stimulate synthesis of glycogen means that it also plays a key role in regulating and boosting the amount of energy released during a workout or activity.

This helps to:

  • Increase endurance– AICAR’s ability to increase synthesis of protein and increase energy levels in the body allows your muscles to perform at a more consistent rate over an extended period without showing signs of fatigue during workouts.
  • Increase burning of fat– by increasing energy in the body, AICAR helps to reduce the conversion of sugar to body fat. When normal energy sources (glucose) are depleted, your body turns to burning fat as a source of energy to cater for the shortage. This leads to formation of lean muscle and reduction of fat deposits.

Protects and Treats Cardiac Ischemic Injuries

Interestingly, AICAR can also protect against ischemic injury. This injury restricts flow of blood to various body tissues thereby leading to insufficient supply of glucose and oxygen. This can cause conditions such as embolisms, thrombosis, and vasoconstriction.

Ischemic injuries can either be asymptomatic or manifest themselves through chest pain caused by angina pectoris. Luckily, with AICAR, sufferers can enhance blood supply to the myocardium (heart), which is key in overcoming such symptoms and conditions.

However, it’s important to mention that there’s still a lot of scientific studies being conducted in relation to AICAR and its benefits right now. In fact, most of what we’ve outlined here as benefits is still in the research phase as it awaits conclusive findings. All in all, endurance athletes and bodybuilders who use AICAR to enhance their performance can easily attest to these benefits.

Potential Side Effects of AICAR


The most concerning side effects of this peptide are the direct effects it causes to the heart. Studies have shown that it can easily lead to enlarged growth of cardiac, tissues thereby affecting blood flow to vital organs such as the brain. Fortunately, these effects are often very minimal especially if you use the right dosage for the recommended time.

Here are other side effects of AICAR

  • Possible defects to the heart valves
  • Problems with bowls
  • Dry mouth
  • Lack of hunger
  • Problems with blood flow

Use and Application of AICAR


AICAR comes in powder form which, when added to a saline solution, dilutes to become an injectable. Regarding the dosage, this depends on your goals as an athlete. In case you are recovering from an injury, the dosage should be 50-100 mg. Injections should be made every day. In case you want to maintain your shape during training, the dosage should be 10-50 mg.

You can also use several other supplements meant to restore the strength of ligaments and joints.

AICAR is used mainly to improve endurance and to protect previously gained muscle mass. This is why it’s so popular among athletes in different sports – such as power and long distances races – to provide sufficient endurance.

To achieve maximum benefit when using this peptide while simultaneously reducing any of its side effects, it’s crucial that you administer proper dosage. However, the issue of AICAR dosage, as mentioned earlier, is still up for debate as the product is still in its testing phases. Nonetheless, you can use these three factors to determine the correct dosage for your body:

1. Body Type

Considering that AICAR is termed as a weight loss peptide, it’s particularly popular among endurance athletes and obese people. The more endurance you’re looking for, the higher the dosage you should take. However, avoid overdosing as this can lead to unpleasant side effects. The widely accepted dosage for general use should be anything around 500mcg per kilogram of body weight per day. Besides, you should take it for a maximum of three days per week, regardless of your body weight.

2. Activity Frequency

AICAR is also termed as an “Exercise in a Pill” because of the benefits it provides in terms of weight loss and muscle growth while having little or no exercises. Therefore, aside from body weight, you also need to consider the activities you are conducting on a regular basis when using this product. For example, if you only conduct simple cardiovascular exercises such as jogging, rope skipping or even none at all, then you possibly need more AICAR dosage for you to see the desired effects. However, for those who conduct strenuous workouts such as heavy lifters, the standard recommended dosage for AICAR should be sufficient.

3. Price

Unfortunately, not everyone can afford to consistently follow the recommended dosage levels of AICAR. In fact, a majority of people take about 100mcg per day which, while still safe and effective, may not offer the same benefit as the recommended dosage. The reason for this peptide’s high price is because it’s still in its testing phase and, therefore, its supply is quite low at present. We however expect this situation to change at some point soon when production increases.

Where to Buy AICAR Online


Like all other bodybuilding products, it’s important to ensure you buy AICAR only from reputable online dealers with proven track records. Besides, ensure that you carefully confirm the purity level of your product before purchasing it. For example, genuine AICAR should have a purity level of over 99%. This way, you can be sure you’re using a safe product that also guarantees you effective results.

Here at Xtrem Supplements, we stock high-quality AICAR from Lifetech Labs. This is without a doubt one of the most trusted laboratories when it comes to producing peptides.

Check out the affordable 50mg/vial AICAR variant that we have in stock here.

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